-If there are microtransactions please don't make them of the destroyable item variety as the asian cash shop games try to juice you with items that have a 10 percent chance of upgrading fully and a 90% chance of exploding even if you buy the insurance and a default of extremely crippled inventory space etc. (Dragon Nest, Maple Story) Cosmetic items are fine but the other stuff ends up amounting to extortion and online gambling, not RPG play.
As to the "destroyable item variety"
IF you put this in the game, and you should think REALLY hard before you do, it can only apply to certain types of gear/things.
SR already has some rules for this.
*Lifestyle cost - your house degrades if you don't take care of it. Like IRL.
*Armor Degradation - from Arsenal. People without the Armorer skill would have to pay to keep it up or
buy new armor all the time.
*Program Degradation - For those S.O.T.A. hacker proggys to stay cutting edge you have to "patch" them.
Or alternately you could just have a fee for everyone's ComLink to stay up to date, unless of course
you're a hacker and can patch it yourself. (But that takes time,

)
*Medkits - don't have the variable chance that you don't use up the stuff in them. Make medkits have
"charges".
Now things like Guns, foci, running gear, swords.....etc etc etc,
Physical "hold it in yer hand" objects should never just "run out of time". If I cache a ton of ammo some time because I hit a good pay off and want to prep for the future, it had damn well not just Vanish because I didn't use it for a month.
Or I snagged a niffty new Power Foci from that corp sec mage last run, and it turns out to be a BIG one. I won't have the karma to bond that sucker for awhile. So I chuck it in my desk drawer for a few months to save the karma i need; BUT when I go back to the drawer, Oh look it turned to dust I took too long and it expired...............
That will kill this just as fast as anything else would.